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KMID : 1009020240220010033
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Clinical Psychopharmacology and Neuroscience
2024 Volume.22 No. 1 p.33 ~ p.44
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Exploring Clinical Subgroups of Participants with Major Depressive Disorder that may Benefit from Adjunctive Minocycline Treatment
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Gerard Anmella
Alcy Meehan
Melanie Ashton
Mohammadreza Mohebbi
Giovanna Fico
Chee H. Ng
Michael Maes
Lesley Berk
Michele De Prisco
Ajeet B. Singh
Gin S. Malhi
Michael Berk
Seetal Dodd
Diego Hidalgo-Mazzei
Iria Grande
Isabella Pacchiarotti
Andrea Murru
Eduard Vieta
Olivia M. Dean
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Abstract
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Objective: To explore illness-related factors in patients with major depressive disorder (MDD) recipients of adjunctive minocycline (200 mg/day) treatment. The analysis included participants experiencing MDD from a 12-week, double blind, placebo-controlled, randomized clinical trial (RCT).
Methods: This is a sub-analysis of a RCT of all 71 participants who took part in the trial. The impact of illness chronicity (illness duration and number of depressive episodes), systemic illness (endocrine, cardiovascular and obesity), adverse effects and minocycline were evaluated as change from baseline to endpoint (12-week) using ANCOVA.
Results: There was a consistent but statistically non-significant trend on all outcomes in favour of the use of adjunctive minocycline for participants without systemic illness, less illness chronicity, and fewer adverse effects.
Conclusion: Understanding the relationship between MDD and illness chronicity, comorbid systemic illness, and adverse effects, can potentially better characterise those individuals who are more likely to respond to adjunctive anti-inflammatory medications.
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KEYWORD
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Minocycline, Depression, Treatment, Clinical trial, Theragnostic, Inflammation
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